Week 1’s highest total is on Bills–Ravens, and it’s in primetime. Kickoff is Sunday, Sept. 7, 2025 at 8:20 p.m. ET from Highmark Stadium. Watch on NBC or stream on Peacock, with pregame coverage on Football Night in America. Baltimore opened -1.5 with a 50.5 over/under. Josh Allen and Lamar Jackson headline a heavyweight AFC clash that could echo in January.
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